Interesting story in Nature highlighting instances where instead of doing post-docs, young biologists have raised funding to set up their own companies. Of course, most start-ups fail, but then most really interesting research projects should fail. Y Combinator is getting into this area, which surprised me. As the age of getting your first grant gets higher, and with the increasingly dysfunctional nature of much academic (medical) science, the attractions are obvious. I was sceptical (and still am) that the ‘software’ model would work in this area.